Abstract
This paper experimentally demonstrates a biological NAND logic gate using DNA and biological nanopores. Biological nanopores can be used for single molecule detection; in our previous works, it was confirmed that ssDNA is driven throughαHL, a biological nanopore, incorporated in bilayer lipid membranes(BLMs) but not double-stranded DNA(dsDNA). In this study, these passing and non-passing phenomena were applied as the binary system and logic gates, and NAND gate was successfully demonstrated. Furthermore, we developed this NAND system into four droplet network. Droplets are covered with lipid and linked through biological nanopores. This droplet network enabled DNA to be input by voltage ON/OFF application. We believe that this system enables direct connection between electrical systems and computing based on biomolecules.
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