Abstract

The adoptive transfer of chimeric antigen receptor T cells (CAR-T cells) has demonstrated impressive clinical benefits in patients with hematological malignancies, however, no equivalent successes have been observed yet in solid tumors. The unsatisfactory outcome with solid tumors could be partly attributed to the lack of appropriate tumor-specific antigens. Here, we describe a novel strategy of tumor retargeting universal chimeric antigen receptor T cell therapy (TRUE-CAR T).

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