1994 EXTERNAL VALIDATION OF THE PREOPERATIVE KARAKIEWICZ NOMOGRAM IN A MULTI CENTER SERIE OF PATIENTS WITH RENAL CELL CARCINOMA TREATED WITH RADICAL OR PARTIAL NEPHRECTOMY

Abstract

You have accessJournal of UrologyKidney Cancer: Advanced1 Apr 20111994 EXTERNAL VALIDATION OF THE PREOPERATIVE KARAKIEWICZ NOMOGRAM IN A MULTI CENTER SERIE OF PATIENTS WITH RENAL CELL CARCINOMA TREATED WITH RADICAL OR PARTIAL NEPHRECTOMY P. Gontero, G. Martorana, R. Schiavina, A. Antonelli, C. Simeone, S. Cosciani Cunico, A. Minervini, L. Masieri, A. Simonato, N. Longo, C. Imbimbo, F. Montorsi, G. Novara, A. Volpe, S. Siracusano, R. Bertini, G. Carmignani, G. Morgia, V. Mirone, and V. Ficarra P. GonteroP. Gontero Torino, Italy More articles by this author , G. MartoranaG. Martorana Bologna, Italy More articles by this author , R. SchiavinaR. Schiavina Bologna, Italy More articles by this author , A. AntonelliA. Antonelli Brescia, Italy More articles by this author , C. SimeoneC. Simeone Brescia, Italy More articles by this author , S. Cosciani CunicoS. Cosciani Cunico Brescia, Italy More articles by this author , A. MinerviniA. Minervini Florence, Italy More articles by this author , L. MasieriL. Masieri Florence, Italy More articles by this author , A. SimonatoA. Simonato Genova, Italy More articles by this author , N. LongoN. Longo Naples, Italy More articles by this author , C. ImbimboC. Imbimbo Naples, Italy More articles by this author , F. MontorsiF. Montorsi Milan, Italy More articles by this author , G. NovaraG. Novara Padua, Italy More articles by this author , A. VolpeA. Volpe Novara, Italy More articles by this author , S. SiracusanoS. Siracusano Trieste, Italy More articles by this author , R. BertiniR. Bertini Milan, Italy More articles by this author , G. CarmignaniG. Carmignani Genova, Italy More articles by this author , G. MorgiaG. Morgia Catania, Italy More articles by this author , V. MironeV. Mirone Naples, Italy More articles by this author , and V. FicarraV. Ficarra Padua, Italy More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2221AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To validate the Karakiewicz nomogram using preoperative variables to predict cancer-specific survival of patients undergoing radical or partial nephrectomy for RCC. METHODS We collected retrospectively the data of 3364 patients surgically treated for RCC in 16 academic centers involved in the Surveillance And Treatment Update Renal Neoplasms (SATURN) project. Univariable and multivariable Cox regression models addressed cancer-specific mortality. Concordance index was used to evaluate the prognostic accuracy of the nomogram 12, 24, 60, and 120 months after surgery. RESULTS All the variable included in the nomograms (age, gender, mode of presentation, clinical tumor size, clinical T stage, presence of metastasis) were independent predictor of CSS in multivariable analysis (all p values <0.02). The prognostic accuracy of the nomogram was 87.8% (IC95% 84.4–91.4) at 12-mo; 87% (IC95% 84.4–89.5) at 24-mo; 84% (IC95% 82.3–87.1) at 60-mo; and 85.9% (IC95% 83.2-88.6) at 120-mo from surgery. Calibrations curve showed that the nomogram tended to significantly overestimate the rates of freedom from cancer-specific mortality a 60 and 120-mo, whereas the differences between estimates and observed rates at 12- and 24-mo were limited. CONCLUSIONS Karakiewicz nomograms has a high prognostic accuracy both in short and long term evaluation of cancer-related outcome of patients with RCC. However, according to our series, the nomograms tend to underestimate the risk of cancer-specific deaths both 60 and 120-mo after surgery. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e798 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information P. Gontero Torino, Italy More articles by this author G. Martorana Bologna, Italy More articles by this author R. Schiavina Bologna, Italy More articles by this author A. Antonelli Brescia, Italy More articles by this author C. Simeone Brescia, Italy More articles by this author S. Cosciani Cunico Brescia, Italy More articles by this author A. Minervini Florence, Italy More articles by this author L. Masieri Florence, Italy More articles by this author A. Simonato Genova, Italy More articles by this author N. Longo Naples, Italy More articles by this author C. Imbimbo Naples, Italy More articles by this author F. Montorsi Milan, Italy More articles by this author G. Novara Padua, Italy More articles by this author A. Volpe Novara, Italy More articles by this author S. Siracusano Trieste, Italy More articles by this author R. Bertini Milan, Italy More articles by this author G. Carmignani Genova, Italy More articles by this author G. Morgia Catania, Italy More articles by this author V. Mirone Naples, Italy More articles by this author V. Ficarra Padua, Italy More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...