Abstract
Leukocytes exert about 1000 times more resistance to the passage of 5 μm diameter filler pores than erythrocytes. Thus, in whole blood with a 1:1000 ratio of white to red cells, about 50 % of the flow resistance is provided by the leukocytes. The whole blood of healthy neonates contains more leukocytes (6000-20000) and more immature granulocytes than adult blood. In septicemia, up to 50% of the granulocytes may be immature. Volume and deformability of peripheral immature (band and myelocytes) and mature polymorphonuclar neutrophils (PMN) were studied in venous blood of healthy neonates, children and adults. Metamyelocytes were only found in neonatal blood. Membrane cytoplasm tongues of PMN were aspirated into 2.5 μm (diameter) micropipettes over a period of 1 min.
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