Abstract
Anorectal malformations (ARM) represent a spectrum of congenital disorders that involve abnormal termination of the anorectum. The clinical management of ARM continues to be a challenge for pediatric surgeons, and our current understanding of the normal and abnormal development of the hindgut remains incomplete. It has been shown that Shh null-mutant mice exhibit persistent cloacae. Furthermore, we have previously shown that both Wnt5a and Fgf10 knock-out mice also exhibit anorectal malformation with full penetrance.
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