Abstract
The proteasome is a multisubunit complex that is responsible for the degradation of many cytosolic proteins. Unlike many other proteolytic enzymes, the proteasome has multiple peptidase activities that can be classified into three main groups: cleavage after hydrophobic side chains (chymotrypsin-like), cleavage after basic residues (trypsin-like), and cleavage after acidic residues (peptidylglutamyl peptide hydrolysis or PGPH). Previous studies have shown that the proteasome is a key route of metabolism for peptide-based non-viral gene delivery systems 1. The gene transfer efficiency of peptide-DNA condensates can be enhanced by the addition of proteasome inhibitors, including MG115, MG132, or epoxomicin.
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