1979 INCIDENCE OF LYMPH NODE METASTASES ABOVE THE ILIAC BIFURCATION IN PATIENTS UNDERGOING RADICAL CYSTECTOMY WITH EXTENDED LYMPH NODE DISSECTION

Abstract

NSAIDs, corticosteroids, finasteride, dutasteride, were not enrolled. On biopsy and on surgical specimens were evaluated changes in flogosis parameters (extensions,and grading according to score of Nickel) and density of Tcells, Bcells and macrophages (mean value of CD20, CD3, CD 68, CD8). RESULTS: Flogosis in the I group at baseline was: extensive (0%), multifocal(80%), focal (20%).The grading was: severe (20%), moderate (80%), mild (20%). After 6 months extension and grade of flogosis was reduced(100% focal;100% mild respectively)(p 0,05). The mean value of CD20, CD3, CD68,CD8, at baseline was of 14.8, 6.4, 5.9, 12.5: after 6 months the mean value was reduced (14.2,6,4.4,5 respectively)(p 0,05). In the subset IIB flogosis was extensive (0%), multifocal(46.1%), focal (53.9%);the grading was severe(7%),moderate(21%), mild(72%). The mean value of CD20, CD3, CD68, CD8 was respectively 40.6, 18.6, 6.7, 6. The subset IIA showed a reduction in the extension (focal 74%, multifocal 26%; extensive 0%),and in the grade of flogosis(mild 75%; moderate 20.8%; severe 4.1%)(p 0,05). Mean value of CD20, CD3,CD68, CD8 was 25.8, 12.7, 5.3, 4.1 respectively: analyzing the results we have a statistically significant reduction of Tcells, Bcells and macrophages(p 0,05). CONCLUSIONS: SeR LY Se may have an anti-inflammatory activity that might be of particular interest in BPH treatment.