1976 ROLE OF COMBINED USE OF KETOCONAZOLE AND TAMSULOSIN IN THE MANAGEMENT OF ACUTE URINARY RETENTION DUE TO BENIGN PROSTATIC OBSTRUCTION

Abstract

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Medical and Hormonal Therapy1 Apr 20111976 ROLE OF COMBINED USE OF KETOCONAZOLE AND TAMSULOSIN IN THE MANAGEMENT OF ACUTE URINARY RETENTION DUE TO BENIGN PROSTATIC OBSTRUCTION Osama Elgamal, Mohamed Elbendary, and Mohamed Taha Osama ElgamalOsama Elgamal Tanta, Egypt More articles by this author , Mohamed ElbendaryMohamed Elbendary Tanta, Egypt More articles by this author , and Mohamed TahaMohamed Taha Tanta, Egypt More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2201AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Ketoconazole is an imidazole derivative that has been shown to block testosterone synthesis and can lower testosterone concentration to castrate levels within 48 hours. We investigated the effect of addition of ketoconazole to tamsulosin in cases of acute urinary retention (AUR) due to benign prostatic obstruction. METHODS The patients presented with AUR for the first time due to benign prostatic obstruction (BPO) were included in this study. Patients with hepatic or renal impairments were excluded. After urethral catheterization, the selected patients were randomized into 2 groups. The first group (23 patients) received tamsulosin 0.4 mg/day while the second one (22 patients) was given tamsulosin plus ketoconazole 200 mg three times daily. The urethral catheter was kept in place and drugs were maintained for 7 days. Patients were put on trial without catheter (TWOC) and those who voided were evaluated with peak flow rate (PFR) and post-void residual urine volume (PVRV) assessment with abdominal ultrasound. RESULTS The mean age of the patients was 64.2 ± 6.3 and 66.4 ±5.1 years and the mean prostate size was 65.7 ± 12.5 and 68.5 ± 11.7 cc for the first and the second groups respectively with no significant difference between both groups. The received medications were well tolerated by all patients with no reported significant side effects. The first and the second groups had successful TWOC in 43.5% (10/23) and 77.3% (17/22) respectively (p=0.03). Among those who had a successful TWOC, the peak flow rate was 7.3 ± 1.4 versus 8.9 ± 1.2ml/s (p= 0.02) and the post-void residual urine volume was 135.6 ± 24.7 versus 114.2 ± 15.8 ml (p= 0.03) in the tamsulosin and the combined treatment groups respectively. CONCLUSIONS Ketoconazole can increase the success rate of trial without catheter in patients with benign prostatic obstruction. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e791 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Osama Elgamal Tanta, Egypt More articles by this author Mohamed Elbendary Tanta, Egypt More articles by this author Mohamed Taha Tanta, Egypt More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...