1975 LONG-TERM EFFICACY OF SILODOSIN ON THE LOWER URINARY TRACT FUNCTION IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA: ASSESSMENT ACCORDING TO PROSTATE SIZE BASED ON PRESSURE-FLOW STUDY

Abstract

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Medical and Hormonal Therapy1 Apr 20111975 LONG-TERM EFFICACY OF SILODOSIN ON THE LOWER URINARY TRACT FUNCTION IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA: ASSESSMENT ACCORDING TO PROSTATE SIZE BASED ON PRESSURE-FLOW STUDY Yoshihisa Matsukawa, Ryohei Hattori, Masashi Kato, Tokunori Yamamoto, and Momokazu Gotoh Yoshihisa MatsukawaYoshihisa Matsukawa Nagoya, Japan More articles by this author , Ryohei HattoriRyohei Hattori Nagoya, Japan More articles by this author , Masashi KatoMasashi Kato Nagoya, Japan More articles by this author , Tokunori YamamotoTokunori Yamamoto Nagoya, Japan More articles by this author , and Momokazu GotohMomokazu Gotoh Nagoya, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2200AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Long-term efficacy of α1-adrenoceptor (AR) antagonist in patients with large prostate is of debate. We prospectively investigated the long-term effect of silodosin on the lower urinary tract function in patients with benign prostate hyperplasia (BPH) according to prostate size, using pressure-flow study(PFS). METHODS Silodosin of 8 mg/day was administered to patients with BPH. The patients were classified into 2 groups according to prostate size; small prostate group (SP) (prostate volume <35ml) and large prostate group (LP) (>= 35 ml). Changes in parameters from baseline to 4 weeks and 1 year after administration were assessed in international prostate symptom score (IPSS), and voiding and storage function as measured by PFS. RESULTS Available data from 102 of enrolled 110 patients were analyzed. At baseline, no significant difference was observed in IPSS between LP (n=50, mean prostate volume: 54.3ml) and SP (n=52, 30.6ml). PFS revealed no significant difference in bladder capacity at first desire to void (FDV) and maximum cystometric capacity (MCC), while detrusor pressure at maximum flow rate (PdetQmax) and bladder outlet obstruction index (BOOI) were significantly higher in LP. The frequency of detrusor overactivity was also significantly higher in LP. At 4 weeks after treatment, both groups showed significant improvement in IPSS with no significant inter-group difference. At 1 year, IPSS further decreased in SP, but increased in LP. In PFS, both groups showed a significant increase in FDV and MCC at 4 weeks and further improvement at 1 year with no significant inter-group difference. Disappearance of detrusor overactivity at 4 weeks and 1 year was observed in 50.0% and 44.1% of LP, and 45.0% and 50.0% of SP, respectively. PFS during the voiding phase at 4 weeks demonstrated a significant decrease in PdetQmax and BOOI regardless of prostate size with no significant inter-group difference. However, although the improvement in PdetQmax and BOOI at 4 weeks was maintained to 1 year in SP, these parameters changed for the worse in LP. CONCLUSIONS Silodosin quickly improves bladder storage function and relieves bladder outlet obstruction, regardless of prostate size. However, in long-term administration, an improvement of bladder outlet obstruction may be reversed in patients with large prostate, despite preservation of an improvement in storage function. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e790-e791 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yoshihisa Matsukawa Nagoya, Japan More articles by this author Ryohei Hattori Nagoya, Japan More articles by this author Masashi Kato Nagoya, Japan More articles by this author Tokunori Yamamoto Nagoya, Japan More articles by this author Momokazu Gotoh Nagoya, Japan More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...