Abstract
Introduction: Highly active antiretroviral therapy (HAART) for HIV infection has been associated with accelerated atherosclerosis and other cardiovascular complications. However, the underlying mechanisms are largely unknown. The objective of this study was to determine the effects and molecular mechanisms of HAART drugs on in vitro cholesterol efflux from human macrophage-derived foam cells, which is a critical factor of atherogenesis. Methods: Human (THP-1) monocyte-derived macrophages were pre-incubated (48 hours) with acetylated low-density lipoprotein and [3H]-cholesterol to form foam cells.
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