195P Breast cancer molecular subtypes markers in subpopulations of circulating tumor cells

Abstract

Molecular subtype of breast cancer is a criterion that determines the treatment tactic and the prognosis of the clinical course of the disease. At the same time, CTCs can arise from the minor subpopulation of primary tumor cells, that do not express target molecules for prescribed therapy. Here we assessed the presence of ER/PR/Her2+ and Ki-67 in subpopulations of CTCs with different manifestations of EMT and stemness, which could dramatically effect on their capacity to migration, proliferation and finally forming a clinically detectable macrometastsis.