1957 DO VASCULAR RISK FACTORS AFFECT LOWER URINARY TRACT SYMPTOMS? PROSPECTIVE STUDY

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You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Non-Neurogenic Voiding Dysfunction1 Apr 20111957 DO VASCULAR RISK FACTORS AFFECT LOWER URINARY TRACT SYMPTOMS? PROSPECTIVE STUDY Won Ki Lee, Dae Yul Yang, Sung Tae Cho, Yong Sung Lee, Dae Sung Kim, Cheol Young Oh, Chang Hee Yu, Jin Seon Cho, Sang Kon Lee, Seong Ho Lee, Sung Yong Kim, and Hayoung Kim Won Ki LeeWon Ki Lee Chuncheon, Korea, Republic of More articles by this author , Dae Yul YangDae Yul Yang Chuncheon, Korea, Republic of More articles by this author , Sung Tae ChoSung Tae Cho Chuncheon, Korea, Republic of More articles by this author , Yong Sung LeeYong Sung Lee Chuncheon, Korea, Republic of More articles by this author , Dae Sung KimDae Sung Kim Chuncheon, Korea, Republic of More articles by this author , Cheol Young OhCheol Young Oh Chuncheon, Korea, Republic of More articles by this author , Chang Hee YuChang Hee Yu Chuncheon, Korea, Republic of More articles by this author , Jin Seon ChoJin Seon Cho Chuncheon, Korea, Republic of More articles by this author , Sang Kon LeeSang Kon Lee Chuncheon, Korea, Republic of More articles by this author , Seong Ho LeeSeong Ho Lee Chuncheon, Korea, Republic of More articles by this author , Sung Yong KimSung Yong Kim Chuncheon, Korea, Republic of More articles by this author , and Hayoung KimHayoung Kim Chuncheon, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2161AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Vascular diseases are presumed to be one of the causes which are responsible for the pathogenesis of lower urinary tract symptoms (LUTS), and it has also been reported that aging-related atherosclerosis or endothelial dysfunction in the pelvic vascular system can cause bladder dysfunction. However, there are no reports of an association between LUTS and vascular risk factors in a population-based study. The aim of this study was to investigate the relationship between LUTS and risk factors for vascular diseases in a population-based cohort study. METHODS Among the 1,520 participants in Chuncheon, Korea, 280 men aged more than 50 years, who underwent detailed health evaluations, including health-related questionnaires, evaluations of their medical history, and various life style factors, as well as clinical measurements, were included in the study. Vascular risk factors used in the present study including hypertension, diabetes mellitus, hyperlipidemia, and smoking and were assessed by medical history and clinical measurements. LUTS were assessed by validated questionnaires, the International Prostate Symptom Score (IPSS), and the relationship between LUTS and vascular risk factors was investigated. RESULTS Of the 280 men, 175 (62.5%) had moderate/severe LUTS (IPSS£¾7) and 260 (93%) had one or more vascular risk factors. The IPSS was similar in those with no (11.6¡¾8.5) vascular risk factors, but increased to 15.1¡¾9.3 in those with 3 or more vascular risk factors (p£¼0.05). The multiple logistic regression analysis, controlling for age and body mass index (BMI) showed that men with 3 or more vascular risk factors were 3 times more likely to have moderate/severe LUTS than men without vascular risk factors (p£¼0.05, Table). Multiple logistic regression results for relative risk of moderate/severe LUTS by age, BMI, and number of vascular risk factors odds ratio of IPSS>7 (95% confidence interval) p value Age 1.05 (1.02–1.08) 0.004 BMI 0.94 (0.86–1.03) 0.155 No. of Vascular risk factors −1–2 compared with 0 1.6 (0.62–4.22) 0.321 −3–4 compared with 0 3.6 (1.19–10.62) 0.024 CONCLUSIONS Men with risk factors for vascular diseases are more likely to have LUTS and these findings suggest that vascular risk factors play a role in the development of LUTS. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e783 Peer Review Report Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Won Ki Lee Chuncheon, Korea, Republic of More articles by this author Dae Yul Yang Chuncheon, Korea, Republic of More articles by this author Sung Tae Cho Chuncheon, Korea, Republic of More articles by this author Yong Sung Lee Chuncheon, Korea, Republic of More articles by this author Dae Sung Kim Chuncheon, Korea, Republic of More articles by this author Cheol Young Oh Chuncheon, Korea, Republic of More articles by this author Chang Hee Yu Chuncheon, Korea, Republic of More articles by this author Jin Seon Cho Chuncheon, Korea, Republic of More articles by this author Sang Kon Lee Chuncheon, Korea, Republic of More articles by this author Seong Ho Lee Chuncheon, Korea, Republic of More articles by this author Sung Yong Kim Chuncheon, Korea, Republic of More articles by this author Hayoung Kim Chuncheon, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...