Abstract
195 Roles of aberrant hemichannel activities due to mutant connexin26 in the pathogenesis of KID syndrome
Highlights
Siah1 expression is associated with keratinocyte differentiation in the epidermis and the hair follicle E Tverye1, EV Solovieva1, SG Rudyak2, L Usakin1 and AA Panteleyev1 1 National Research Center «Kurchatov Institute», Moscow, Russian Federation and 2 Emanuel institute of Biochemical Physics of the Rassian Academy of Science, Moscow, Russian Federation As components of E3 ubiquitin ligase complexes, Siah proteins facilitate ubiquitination and degradation of diverse protein targets and are involved in many biological processes such as apoptosis, hypoxia response, cell cycle control, proliferation and migration
Our artistic and cultural endeavor has an educational purpose; it seeks to communicate knowledge of the physiology of the skin to different audiences by using and disseminating the technique of origami. This exhibition is directed at two audiences: 1)To an audience of initiates, dermatologists and scientists specialized in skin biology who will be able to recognize the basic facts of skin physiology reinterpreted by origami 2) to the general public
We explored the effects of three mouse Cx26 mutants (Cx26-G12R, -G45E and -D50N) corresponding to KID syndrome-causative human mutants on hemichannel activities leading to cell death and the expression of immune response-associated genes
Summary
We employed a comprehensive CRISPR interference (CRISPRi) screen of all epidermally expressed lncRNAs in human progenitor keratinocytes to identify functional lncRNAs regulating their proliferation. Deep characterization of a top hit using RNA interference, identified a lncRNA required for progenitor proliferation, clonogenicity and cell cycle progression, as well as for stratification, differentiation and epidermal barrier formation during organotypic epidermis formation.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
