Abstract
and found that parietal cells in the infected stomach expressed IFNα/β protein in response to Helicobacter infection and that gastric IFNβ mRNA peaked 2 months after the infection while IFNα and IRF7 expression peaked at 2 to 4 months, followed by the peak in Slfn4 mRNA. Ex vivo IFNα11 (800U/ml) treatment of cultured peritoneal myeloid cells induced a phenotypic shift from Gr1-/Slfn4to Gr1+/Slfn4+ cells correlating with a robust increase in Slfn4 expression in vivo. Conclusion: Hedgehog signaling synergizes with Helicobacter infection to induce acquisition of Slfn4+ MDSCs in the stomach.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
