194P Thermal ablation followed by intratumoral injection of a novel immune stimulant IP-001 in patients with advanced solid tumors: Phase IB part of study SAKK 66/17

Abstract

The induction of immunogenic cell death by thermal ablation (TA) with local immunostimulation is a novel approach to address advanced, immune “cold”, treatment-refractory cancer. Glycated N-acetylglucosamine polymer, IP-001® , is a novel immune stimulant that drives the activation of innate immune cells through multiple pathways (Stimulator of Interferon Genes STING, Inflammasome, and others) and acts as an antigen depot, which may enhance downstream adaptive anti-tumor immunity. When combined with TA, IP-001 stimulated abscopal effects at distant, untreated tumors, and immune memory in animal models.