194-POS

Abstract

Objectives Preeclampsia (PE) and IUGR share common pathomechanisms. Recently, we reported on serum lipid concentrations in both conditions in the early-onset form of PE before 34 weeks of gestation (Pecks et al., 2012). Subtle changes of triglyceride concentrations were noticed in PE while a significant decrease in LDL levels was found in IUGR subjects when compared to a control group (CTRL). We now aimed to extend our lipid analysis within our cohort to gain a deeper understanding of lipid metabolism and its role in the pathogenesis of both diseases. Methods Serum of (i) PE, (ii) PE with IUGR, and (iii) normotensive IUGR each n = 10 was matched to a CTRL group (iv, n = 30). HDL, IDL, LDL, VLDL were isolated by sequential preparative ultracentrifugation. Esterified and non-esterified cholesterol, phospholipid, and triglyceride concentrations were determined in each fraction. Statistical analysis was done using 2-way ANOVA. Results No significant difference between the case groups and CTRL could be observed in the HDL fraction. In the IDL fraction triglyceride levels were higher in PE as compared to CTRL. Within the LDL fraction esterified and non-esterified cholesterol and phospholipid levels were lower in IUGR and IUGR + PE. Within the VLDL fraction triglycerides were higher in all three case groups as compared to CTRL (table). Conclusions Our results suggest a disturbed conversion of VLDL to LDL is involved in both IUGR and preeclampsia. Triglyceride metabolism appears to be most affected in preeclampsia whereas cholesterol metabolism is disturbed in IUGR irrespectively of additional preeclampsia. One has to carefully separate all three entities to avoid misinterpretation. Disclosures U. Pecks: None. B. Winkler: None. T. Goecke: None. N. Maass: None. C. Contini: None. K. Winkler: None.