Abstract
Abstract Inositol is a natural extract mainly from Carob, a typical Mediterranean fruit, and small quantities of apples and grapes. Inositol has been associated with several benefits such as antioxidant, capacity, anti-cancer, and hyperglycemia reduction in type 2 diabetes mellitus. However, there is little information regarding the effects of inositol on canine nutrition. This study aimed to evaluate the longitudinal effects of daily supplementation of incremental doses of inositol on serum oxidative stress, inflammatory biomarkers, gut hormones, and postprandial glycemic and insulinemic responses in overweight dogs. Thirty adult dogs were used in a completely randomized study, with 10 animals per treatment. Dogs were fed a commercial dry extruded complete and balanced diet once daily to maintain body weight. Following a 15-d adaptation to the control diet, dogs were fed their respective treatment diets for 60 d. Three experimental treatments were used: 12 g/d of corn syrup (control), 8 g/d of inositol source, and 16 g/d of inositol source. The treatments supplementation had no detrimental effect on the overall health of the dogs and food intake. Throughout the experimental period, serum oxidative stress biomarkers did not differ among dogs fed different dietary treatments (P > 0.05). However, a linear increase across days of the serum cytokine CXCL1 with the supplementation of increasing inositol concentrations was observed (P = 0.0105). Although no differences were observed in the glycemic response to an intravenous glucose tolerance test with the supplementation of increasing concentrations of inositol (P > 0.05), a linear decrease in the average glucose for 24 h measured with interstitial glucose monitors was observed with the supplementation of increasing concentrations of inositol (P = 0.0215). These data suggest that the longitudinal supplementation of inositol may interact with inflammatory response and contribute to the regulation of glucose metabolism.
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