Abstract
Several molecular pathways that regulate hematopoietic stem cell (HSC) self-renewal in the mouse have recently been elucidated, including Notch, HOXB4, Wnt and bone morphogenetic protein signaling pathways. However, full elucidation of the intrinsic and extrinsic mechanisms that regulate human HSC self renewal has yet to be realized. As a model for identifying extrinsic factors that stimulate human HSC self-renewal, we have studied the capacity for vascular endothelial cells to support human HSC expansion ex vivo.
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