1939 LOW PERCENTAGE (

Abstract

You have accessJournal of UrologyProstate Cancer: Detection & Screening (III)1 Apr 20131939 LOW PERCENTAGE (<10%) OF POSITIVE BIOPSY CORE (PBC) IS NOT A PREDICTOR OF LOWER RISK FOR PSA RECURRENCE IN CT1C PROSTATE CANCER TREATED WITH RADICAL PROSTATECTOMY IN CONTEMPORARY JAPANESE POPULATION Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Shintaro Narita, Norihiko Tsuchiya, Koji Mitsuzuka, Sadafumi Kawamura, Tomonori Habuchi, Yoichi Arai, and Chikara Ohyama Shingo HatakeyamaShingo Hatakeyama Hirosaki, Japan More articles by this author , Takahiro YoneyamaTakahiro Yoneyama Hirosaki, Japan More articles by this author , Yasuhiro HashimotoYasuhiro Hashimoto Hirosaki, Japan More articles by this author , Takuya KoieTakuya Koie Hirosaki, Japan More articles by this author , Shintaro NaritaShintaro Narita Akita, Japan More articles by this author , Norihiko TsuchiyaNorihiko Tsuchiya Akita, Japan More articles by this author , Koji MitsuzukaKoji Mitsuzuka Sendai, Japan More articles by this author , Sadafumi KawamuraSadafumi Kawamura Sendai, Japan More articles by this author , Tomonori HabuchiTomonori Habuchi Akita, Japan More articles by this author , Yoichi AraiYoichi Arai Sendai, Japan More articles by this author , and Chikara OhyamaChikara Ohyama Hirosaki, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2358AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES High percentage of positive biopsy cores (PBC) has been reported to be a useful predictor of PSA recurrence after radical prostatectomy. However, it is not well known whether low percentage of PBC can predict lower PSA recurrence risk. We investigated whether low percentage of PBC has potential to predict favorable outcome in PSA recurrence in cT1c prostate cancer. METHODS The records of 1268 consecutive cases with localized prostate cancer who were treated radical prostatectomy without neoadjuvant therapy from Jan 2001 to Dec 2009 were retrospectively reviewed. We identified 681 cases with T1c cases. They were divided into 3 groups according to percentage of PBC; low percentage PBC group who had ≤10% PBC, intermediate PBC group who had 11–74% PBC, and high PBC group who had 75-100% PBC. Preoperative factors including age, initial PSA, percentage of PBC, biopsy GS, D'Amico risk were compared among the 3 groups. The PSA recurrence free survival was estimated by Kaplan-Meier method, and multivariate analysis was used to analyze the predicting pT3, and PSA recurrence. RESULTS Of 681 patients, 164 were included in low PBC group, 503 were in intermediate PBC group and 14 were in high PBC group. Median follow-up periods were 47 months. There were no significant differences in age, iPSA, biopsy Gleason Scores among the groups. Number of biopsy, percentage of PBC and incidence of pT3 were significant higher in intermediate and high PBC group compared with low PBC group. PSA recurrence free survival was significantly low in high PBC group. However, there was no significant difference between low PBC and intermediate PBC groups. Multivariate analysis showed low percentage of PBC was independent factor for pathological organ confinement, while it did not have significant association with low risk of PSA recurrence. CONCLUSIONS A low percentage (≤10%) positive biopsy core is not a predictor for low risk of PSA recurrence in cT1c prostate cancer that is treated with radical prostatectomy. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e795 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Shingo Hatakeyama Hirosaki, Japan More articles by this author Takahiro Yoneyama Hirosaki, Japan More articles by this author Yasuhiro Hashimoto Hirosaki, Japan More articles by this author Takuya Koie Hirosaki, Japan More articles by this author Shintaro Narita Akita, Japan More articles by this author Norihiko Tsuchiya Akita, Japan More articles by this author Koji Mitsuzuka Sendai, Japan More articles by this author Sadafumi Kawamura Sendai, Japan More articles by this author Tomonori Habuchi Akita, Japan More articles by this author Yoichi Arai Sendai, Japan More articles by this author Chikara Ohyama Hirosaki, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...