193 EFFECTS OF DESMOPRESSIN PLUS PROPIVERINE FOR THE TREATMENT OF MONOSYMPTOMATIC PRIMARY NOCTURNAL EENURESIS IN CHILDREN

Abstract

INTRODUCTION AND OBJECTIVES: We evaluated the efficacy of a combination treatment of desmopressin and propiverine for treating children with monosymptomatic primary nocturnal enuresis. METHODS: A total of 53 children aged 6 to 15 years old with monosymptomatic nocturnal enuresis were enrolled in this prospective study. Children with a minimum of 3 wet nights weekly were included. Children were randomly assigned groups and treated with desmopressin 0.2mg, or a combination of desmopressin plus propiverine 10mg. Of these patients 43 (31 boys and 12 girls, mean age 8.4 2.5 years, range 4 to 13) were followed for more than 6 months. Efficacy was measured at 1, 3 and 6 months in terms of average enuretic frequency after treatment. RESULTS: Of the 43 children finally analyzed, 23 received combination therapy of desmopressin and propiverine and 20 received desmopressin alone. The frequency of nocturnal enuresis at baseline in the monotherapy group and combination therapy group was similar (5.45 1.57 vs 5.82 1.44). However, a decrease of the nocturnal enuresis was significantly pronounced in the combination group after 6 months treatment than in monotherpy group (2.2 1.01 vs 1.29 0.67). Combination therapy produced better outcomes than monotherapy in terms of the number of nocturnal enuresis episodes (p 0.017). Adverse events were minimal. CONCLUSIONS: Combination therapy with desmopressin plus propiverine for the treatment of monosymptomatic nocturnal enuresis was well tolerated, and gave effective results in reducing enuresis episodes rather than a single therapy of desmopressin in children.