1926 PREDICTING FACTORS FOR INSIGNIFICANT CANCER AFTER A DIAGNOSIS OF ONE SINGLE MINUTE FOCUS OF PROSTATE CANCER ON NEEDLE BIOPSY

Abstract

You have accessJournal of UrologyProstate Cancer: Detection and Screening1 Apr 20111926 PREDICTING FACTORS FOR INSIGNIFICANT CANCER AFTER A DIAGNOSIS OF ONE SINGLE MINUTE FOCUS OF PROSTATE CANCER ON NEEDLE BIOPSY Vincenzo Scattoni, Luca Villa, Firas Abdollah, Giovanni Petralia, Diego Angiolilli, Carmen Maccagnano, Andrea Gallina, Alberto Briganti, Nazareno Suardi, Massimo freschi, Claudio Doglioni, Patrizio Rigatti, and Francesco Montorsi Vincenzo ScattoniVincenzo Scattoni Milan, Italy More articles by this author , Luca VillaLuca Villa Milan, Italy More articles by this author , Firas AbdollahFiras Abdollah Milan, Italy More articles by this author , Giovanni PetraliaGiovanni Petralia Milan, Italy More articles by this author , Diego AngiolilliDiego Angiolilli Milan, Italy More articles by this author , Carmen MaccagnanoCarmen Maccagnano Milan, Italy More articles by this author , Andrea GallinaAndrea Gallina Milan, Italy More articles by this author , Alberto BrigantiAlberto Briganti Milan, Italy More articles by this author , Nazareno SuardiNazareno Suardi Milan, Italy More articles by this author , Massimo freschiMassimo freschi Milan, Italy More articles by this author , Claudio DoglioniClaudio Doglioni Milan, Italy More articles by this author , Patrizio RigattiPatrizio Rigatti Milan, Italy More articles by this author , and Francesco MontorsiFrancesco Montorsi Milan, Italy More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2064AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES to identify factors predicting the presence of an insignificant prostate cancer, according to Epstein criteria at radical prostatectomy (RP) in patients with one single minute focus patients on needle biopsy. METHODS In our series of 7450 consecutive needle biopsies performed from November 1992 to April 2009, we analyzed 448 patients (6%) with a single microfocus of prostate cancer (one single neoplastic lesion ≤ 5% in one biopsy core or ≤ 0.5 mm in length with Gleason score ≤ 6). (N=4600 >12 core biopsy, N=2850 ≤ 12-core biopsy). Out of 448 patients, 96 (21%) were submitted to ≤12-core biopsy, while the remaining 352 (79%) were submitted to > 12-core biopsy. Out of 448 patients, 201 were treated with radical prostatectomy (RP). Univariate and multivariate analysis were used to identify independent predictors on biopsy, including age, total PSA, clinical stage, Gleason score on biopsy, prostate volume (PV) of insignificant prostate cancer on RP. RESULTS The incidence of a single minute focus was higher in patients submitted to >12-core biopsy cores than those submitted to ≤ 12-core biopsy (7,6% vs 3,36%; p<0,01). After RP, an insignificant prostate (tumor volume ≤ 0.5 cc) was detected in 87 (43,2%) patients. At univariate and multivariate analysis, only prostate volume was predictive of the presence of insignificant prostate cancer (60.27 cc vs. 78,74 cc, p=0,02) (OR=0.98, p=0.03) while the other parameters (age, pre-operative PSA, number of cores, time at needle biopsy) were not correlated with the presence of insignificant cancer. CONCLUSIONS The risk of finding a single microfocus of prostate cancer is significantly higher in patients submitted to >12-core biopsy than patients submitted to ≤12-core biopsy. Patients with a larger prostate seem to have a higher risk of having an insignificant prostate cancer after RP than patients with smaller prostate. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e770 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Vincenzo Scattoni Milan, Italy More articles by this author Luca Villa Milan, Italy More articles by this author Firas Abdollah Milan, Italy More articles by this author Giovanni Petralia Milan, Italy More articles by this author Diego Angiolilli Milan, Italy More articles by this author Carmen Maccagnano Milan, Italy More articles by this author Andrea Gallina Milan, Italy More articles by this author Alberto Briganti Milan, Italy More articles by this author Nazareno Suardi Milan, Italy More articles by this author Massimo freschi Milan, Italy More articles by this author Claudio Doglioni Milan, Italy More articles by this author Patrizio Rigatti Milan, Italy More articles by this author Francesco Montorsi Milan, Italy More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...