Abstract
A wealth of data exists correlating individual rejection episodes with clinical outcomes following heart transplantation. We have previously noted that heart transplant recipients also develop rejection patterns of clinical importance early after transplantation. The effect these patterns have on outcomes are not universally known or accepted. In this study, we sought to analyze whether repetitive episodes of cellular (CR) or antibody-mediated rejection (AMR) impact cardiovascular (CV) death incrementally in a large cohort of heart transplant recipients followed for up to 20 years.
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