192: OUTCOME IMPROVEMENTS IN AORTIC DISSECTION PATIENTS WITH INTENSIVE CARE UNIT USE OF STATIN

Abstract

Introduction: Aortic dissection is a life-threatening emergency condition that requires immediate interventions and therapies. The in-hospital mortality rate varies from 10% to 20%, depending on the type, location, and severity of dissection. Clinical data further highlight the association between oxidation, inflammation, and in-hospital mortality in aortic dissection patients. Statin possesses potent anti-oxidation and anti-inflammation capacity. We conjectured that use of statin in intensive care unit (ICU) may improve the outcomes of aortic dissection patients. To explicate this matter in question, we performed this retrospective cohort study analyzing data retrieved from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. Methods: Through exploring the MIMIC-IV database, we identified aortic dissection patients admitted to ICU and retrieved relevant data for analysis. The Chi square test was performed to compare the between-group differences in the in-hospital mortality and overall mortality rates. Moreover, logistic regression analysis was performed to elucidate the impacts of ICU statin use on in-hospital mortality and overall mortality. Results: A total of 432 subjects were included. Among them, 223 subjects (51.62%) received statin after ICU admission (the Statin group) and 209 subjects (48.38%) did not use statin during hospitalization (the no-Statin group). Our data revealed that the in-hospital mortality rate and overall mortality rate in the Statin group (5.38% and 8.97%, respectively) were significantly lower than those in the non-Statin group (18.66% and 22.97%, respectively) (both p < 0.001). Data of logistic regression analysis further demonstrated that, comparing to the non-Statin group, the risks of in-hospital mortality (odd’s ratio [OR]: 0.25, 95% confidence intervals [CI]: 0.13~0.49, p < 0.001) and overall mortality (OR: 0.33, 95% CI: 0.19~0.58, p < 0.001) in the Statin group were significantly lower. Conclusions: Data from this retrospective cohort study support the relationship between use of statin in ICU and outcome improvements in aortic dissection patients.