1912 CHANGES IN SERUM PROSTATE SPECIFIC ANTIGEN FOLLOWING HOLMIUM LASER ENUCLEATION OF THE PROSTATE IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA

Abstract

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Surgical Therapy and New Technology I1 Apr 20101912 CHANGES IN SERUM PROSTATE SPECIFIC ANTIGEN FOLLOWING HOLMIUM LASER ENUCLEATION OF THE PROSTATE IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA Jun Nakashima, Hidaka Kono, Eiji Kikchi, Hirohiko Nagata, Akira Miyajima, Ken Nakagawa, Masaaki Tachibana, and Mototsugu Oya Jun NakashimaJun Nakashima More articles by this author , Hidaka KonoHidaka Kono More articles by this author , Eiji KikchiEiji Kikchi More articles by this author , Hirohiko NagataHirohiko Nagata More articles by this author , Akira MiyajimaAkira Miyajima More articles by this author , Ken NakagawaKen Nakagawa More articles by this author , Masaaki TachibanaMasaaki Tachibana More articles by this author , and Mototsugu OyaMototsugu Oya More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1879AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Holmium laser enucleation of the prostate (HoLEP) has become a useful technique for the treatment of benign prostatic hyperplasia (BPH). However, few studies to date have evaluated the correlation between the change of serum prostate specific antigen (PSA) and effects on volume by HoLEP. The present study was undertaken to evaluate the clinical implication of the PSA changes in the assessment of volume reduction following HoLEP. METHODS The present study includes 68 patients with BPH who have undergone HoLEP for BPH and in whom complete data of PSA were available. Patients who have prostate cancer on histological examination are not included in this study. Serum levels of PSA were measured before and after HoLEP. Prostate volume and transition zone (TZ) volume were measured by transrectal ultrasonography (TRUS) before HoLEP. The changes of serum PSA were correlated with the volume parameters such as the preoperative volume, resected volume, change in the volume and so on. The gravity of the adenoma was estimated to 1g/cc. RESULTS The mean preoperative volume of the prostate and TZ (cc) and the resected volume (g) were 82.8±3.3, 49.4±2.6 and 46.1±3.2, which were significantly correlated with each other. The strong correlation between TZ volume (x) and resected volume (y) (y= -2.2+0.98x, r=0.80) suggests that almost entire TZ volume can be resected by HoLEP. Serum PSA were decreased from 11.5±1.7 to 1.2±0.1 ng/ml with a reduction rate of 84%. The decrease of serum PSA per 1g of resected tissue was 0.27±0.04 ng/ml/g. The reduction rate of serum PSA was significantly correlated with the resected volume (r=0.26) and the resection rate (resected volume/prostate volume, r=0.38; resected volume/TZ volume, r=0.25). The decrease in serum PSA following HoLEP was significantly correlated with the resected volume (r=0.26) and the resection rate (r=0.36). The postoperative serum PSA level following HoLEP was significantly correlated with the residual volume (prostate volume - resected volume) (r=0.43). CONCLUSIONS Almost entire TZ volume can be resected by HoLEP. Serum levels of PSA significantly decreased following HoLEP and the changes in the serum PSA reflected the change in the volume parameters of BPH. The changes of serum PSA may be a useful tool to assess the treatment effects on volume reduction by HoLEP. Tokyo, Japan© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e744 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jun Nakashima More articles by this author Hidaka Kono More articles by this author Eiji Kikchi More articles by this author Hirohiko Nagata More articles by this author Akira Miyajima More articles by this author Ken Nakagawa More articles by this author Masaaki Tachibana More articles by this author Mototsugu Oya More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...