Abstract

Background: Anlotinib, an oral multi-targeted tyrosine kinase receptor inhibitor, monotherapy improves OS and PFS as a third-line treatment for stage IV NSCLC. Bevacizumab added to paclitaxel/carboplatin is a standard first-line therapy for advanced non-squamous NSCLC. Previous study has explored the efficacy and safety of anlotinib in combination with chemotherapy as first-line therapy in advanced NSCLC patients. This is the first trial evaluating the combination of chemotherapy and anlotinib in treatment-naïve advanced non-squamous NSCLC.

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