Abstract
Introduction: Cognitive and behavioural responses to food reward are associated with individual differences in reward-responsiveness and impulsivity. There is evidence for decision-making deficits in individuals with obesity and binge-eating disorder. Despite these data, there is a lack of understanding about neural mechanisms contributing to altered motivation and impulsivity for food. Dopamine (DA) neurons in the ventral tegmental area (VTA) of the midbrain and their limbic targets in the nucleus accumbens (NAc) and dorsal striatum (DS), are an essential component of the neural circuitry underlying motivation and reward.
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