190 Lack of association between dietary and supplemental vitamin E intake with skin cancer risk in postmenopausal women

Abstract

Risk factors for cutaneous melanoma (CM) and nonmelanoma skin cancer (NMSC) include fair skin and extensive sun exposure. But, incidence has risen despite efforts to promote sun protection. Thus, identifying methods for therapeutic prevention is needed. Antioxidants such as vitamin E are theorized to reduce cancer risk by scavenging reactive species to reduce oxidative stress and DNA damage, but associations between vitamin E intake and skin cancer risk in women remain unclear. To investigate this, we used data from >93,000 postmenopausal women from the observational arm of the Women’s Health Initiative (WHI).