Abstract
On 182 occasions college coeds with acute, uncomplicated (UTIs), documented by >105 of the same bacteria in two consecutive urine cultures, were randomly treated with amoxicillin 3 gm., single dose (83); 3 gm. double dose at 12 hour intervals (70); and 250 mg. t.i.d. for 10 days (29). Clinical cure rates at one week post therapy in single dose group was 88.0%, double dose group 80.0%, and in 10 day group, 100%. At four weeks post therapy in the single dose group, bacteriological cure rate was 68.7%, reinfections 19.3%, relapse 4.8% and persistence of infection 7.2%; in the double dose group, bacteriological cure rate was 71.4%, reinfection 7.1%, relapse 12.9%, and persistence of infection 8.6%; in 10 day group, bacteriological cure rate was 82.8%, reinfection 3.8%, relapse 3.4%, and no persistence of infection.Conventional Amoxicillin therapy appeared superior to single and double dose; however, the differences were not statistically significant. Single dose appeared easy, safe and practical in acute, uncomplicated UTIs of young women. The drug was tolerated well in all pateints. Complete blood counts, blood chemistries and transaminase enzymes remained normal.
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