18P Low levels of miR-18a is associated with immunosuppression and increased chemo-unresponsiveness in ER-negative tumors

Abstract

Chemotherapy is the main mode of treatment for the ER negative (ER-ve) subtype of breast cancer. However, despite an initial good response there is a high risk of recurrence in this subtype. microRNAs play an important role in mediating this drug resistance by regulation of the tumor-stromal interactions. Here we have explored the role played by miR-18a in immune modulation and chemo-responsiveness in ER-ve breast cancer.