Abstract
Obesity is a life-threatening metabolic disorder necessitating urgent development of safe and effective therapy. Currently, limited such therapeutic measures are available for obesity. The present study was designed to develop a novel, safe and effective herbal therapy for the management of obesity. A polyherbal formulation (18KHT01) was developed by homogeneously mixing a specific proportion of crude Quercus acutissima (acorn jelly powder), Camellia sinensis (dry leaf buds), and Geranium thunbergii (dry aerial part) along with Citrus limon (fruit juice). Synergistic antioxidant, antiadipogenic, and anti-obesity activities were evaluated by in vitro as well as in vivo studies. In vitro experiments revealed strong synergistic antioxidant and anti-adipogenic activities of 18KHT01. Molecular assessment of 18KHT01 showed significant down-regulation of vital adipogenic factors such as PPARγ, C/EBPα, aP2, SREBP-1c, FAS, and LPL. Based on the results of the preliminary toxicity study, 75 and 150 mg/kg, twice daily doses of 18KHT01 were administered to evaluate anti-obesity activity in diet-induced obese (DIO) C57BL/6J mice model. The major obesity-related parameters such as body weight, weight gain, food efficiency ratio, as well as serum lipid profile were significantly reduced by 18KHT01 with potential synergism. Also, the high-fat diet-induced insulin resistance was suggestively alleviated by the formulation, and thus ameliorated fasting blood glucose. Histological evaluation of liver and white adipose tissue revealed that the significant reduction of fat depositions and thus reduction of these tissue weights. Synergy evaluation experiments exhibited that the 18KHT01 offered strong synergism by improving efficacy and reducing the toxicity of its ingredients. Overall results evidenced the 18KHT01 as a safe and potent anti-obesity herbal therapy.
Highlights
Obesity is considered as the accumulation of abnormal or excessive fat into the body to the extent that may impair health conditions
Corilagin, EC, EGCG, and ECG were detected at a wavelength of 210 nm whereas ellagic acid was detected at 254 nm
Results showed that 18KHT01 had better antioxidant activity than that of Q. acutissima, G. thunbergii, and lemon juice, and was comparable with that of C. sinensis, which indicated that a small amount of the ingredients showed similar or better antioxidant activity if they were treated in a combination as 18KHT01
Summary
Obesity is considered as the accumulation of abnormal or excessive fat into the body to the extent that may impair health conditions. Obese people are recommended to modify their lifestyle by increasing physical activity and reducing calories intake for the treatment of obesity. Evidences are arising to support the effectiveness of herbal medicine and polyherbal formulations in the treatment of obesity. Herbal medicines exhibited anti-obesity activity through lipase inhibition, food intake suppression, increase of energy expenditure (thermogenesis), adipogenesis inhibition, lipid metabolism regulation, insulin secretion stimulation, increase of satiety, diuresis stimulation, and by acting on the central nervous system through leptin (Saper et al, 2004; Yun, 2010; Chandrasekaran et al, 2012; Liu et al, 2017). An anti-obesity polyherbal formulation (18KHT01) was developed by homogeneously mixing a specific proportion of crude Q. acutissima (acorn jelly powder), C. sinensis (dry leaf buds), and G. thunbergii (dry aerial part) along with C. limon (fruit juice)
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