Abstract
Rapid high-yield syntheses of the four gaseous monofluoroalkanes, CH 3F, C 2H 5F, n-C 3H 7F and i-C 3H 7F, labeled with 18F are described. The method involves silver (I) oxide catalyzed nucleophilic substitution of 18F − for iodide in the respective iodoalkanes, using acetonitrile as solvent at 120°C. The 18F − was made in a nuclear reactor by irradiation of Li 2CO 3, which was subsequently decomposed with H + form ion exchange resin. The resulting aqueous 18F − was rotary-evaporated to dryness after addition of tetraethylammonium hydroxide. Ostwald solubility coefficients of the gases were determined radiometrically at 37°C in water, 0.9% saline, plasma, blood and paraffin oil. The aqueous solubilities are all near unity, while the values for oil rise from 1 to 12 in the series CH 3F<C 2H 5F< i-C 3H 7F< n-C 3H 7F. Whole- body washout kinetics following equilibration with the 18F gases showed that fluoromethane and fluoroethane, at least, are not metabolized in the rat. The possible utility of 18F-fluoromethane and other 18F gases and vapors in studies of lung-function and blood-flow is discussed.
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