Abstract
Background: The aim of this preliminary study was to determine whether there was metabolic change in the basal ganglia or thalamus in the vascular parkinsonism (VP) patients by 18F-FDG-PET scan. Methods: 6 VP patients (age range: 48-85 years; mean age: 70±14.3 years), 4 Parkinson’s disease (PD) patients(age range: 59-71 years; mean age: 68.5±6.6 years), and 4 normal controls (age range: 53-64 years; mean age:57.5±5.1 years) were enrolled in this study. 18F-FDG-PET brain scan was performed in each patient. Five-millimeter circular regions of interest (ROIs) were used to sample radiotracer specific uptake value (SUV) in the selected basal ganglion and thalamus regions. The mean data of SUV in each selected area were compared between groups. Results: Mann-Whitney test was applied in this study. The SUVs in VP patients (4.09-6.51) were statistically significant lower in bilateral basal ganglia and thalamus regions than in normal controls (5.93-8.59) and PD patients (5.61-9.94) (P ＜ 0.02). There was no significant difference in uptake of 18F-FDG in the basal ganglia and thalamus regionsas compared with PD from normal controls (P ＞ 0.05). Conclusion: Evaluation of glucose metabolic rate at bilateral basal ganglia and thalamus using 18F-FDG PET is valuable in differentiating VP from PD.
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