Abstract
The aim of this paper was to design and synthesis a heterodimeric peptide Arg-Gly-Asp-Tyr-Lys-Ala-Thr-Trp-Leu-Pro-Pro-Arg (RGD-A7R), which is expected to have better performance for dual-receptor targeting. We prepared [18F]AlF-NOTA-RGD-A7R by a direct method with good radiochemical yield and purity in as short as 0.5 h. With reasonably high specificity, this new radio-tracer allowed the visualization of tumors which is VEGF and/or αvβ3 positive. In addition, the tracer also showed favorable pharmacokinetics as an imaging agent.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
