Abstract
PurposeThe aim of this study was to correlate preoperative 3'-deoxy-3'-[18F] fluorothymidine (FLT) uptake with the clinical outcome and survival in these patients after surgery.Materials and MethodsWe performed a prospective analysis in 27 patients with adenocarcinoma of the pancreas (15 males, 12 females, mean age: 62 ± 13 years, range: 34 – 86 years). FLT PET (45 min p.i., 300 MBq FLT; ECAT HR+) images were acquired according to standard protocols. FLT uptake was quantified using standardised uptake values (SUV). Mean follow-up was 35 months (range 24-49). FLT uptake was correlated with survival using Martingale residual analysis.ResultsTwenty-two patients died during follow-up. Mean overall survival was 18.8 months (SD: 12.7 months, 95% CI: 7.7, 26.5). FLT PET showed a mean SUV of 2.5 (range: 1.1 - 6.5). Martingale residual analysis revealed significant correlation between survival and FLT uptake (p = 0.045). The corresponding estimated hazard ratio per one-point increment of SUVmean was 1.298 (95% CI: 1.001, 1.685; p < 0.05).ConclusionsFLT PET allows risk stratification for death in patients with resectable pancreatic cancer prior to surgery.
Highlights
Pancreatic cancer (PC) accounts for approximately 36,800 cancer deaths per year in the United States [1]
The corresponding estimated hazard ratio per one-point increment of SUVmean was 1.298
Analysis of overall survival shows that the prognosis of PC is still extremely poor, despite the fact that 1-year survival has increased from 15% to 21.6% and 5-year survival has increased from 3% to 5% within the last decade [2,3,4]
Summary
Pancreatic cancer (PC) accounts for approximately 36,800 cancer deaths per year in the United States [1]. Analysis of overall survival shows that the prognosis of PC is still extremely poor, despite the fact that 1-year survival has increased from 15% to 21.6% and 5-year survival has increased from 3% to 5% within the last decade [2,3,4]
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