Abstract
TIM-3 is a known marker of T-cell exhaustion but it is also commonly found on leukemia blasts in acute myeloid leukemia (AML). TIM-3 positivity of AML blasts was associated with higher relapse rate and worse overall survival. Although TIM-3 function in AML cells is far from elucidated, TIM-3 was reported to mediate Galectin-9 secretion, and TIM-3/Galectin-9 release in the plasma might contribute to inhibition of T-cell effector function.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
