188P The efficacy of neoadjuvant chemotherapy in patients with advanced colon cancer

Abstract

Background This study aimed to investigate the efficacy studies ofneoadjuvant chemotherapy in patients with advanced colon cancer. Methods 160 colon cancer patients were randomly assigned to an adjuvant chemotherapygroup (n=80) oracontrolgroup(n= 80) fromJanuary2011-June 2015. The preoperative chemotherapy group were treated with FOLFOX chemotherapy for 4 cycles. The preoperative chemotherapy group underwent radical surgery after chemotherapy ended on 21d. The control group underwent radical surgery which did not work. Two groups were treated postoperatively with 4 cycles ofchemotherapy. The treatment effect oftwo groups were compared. Results:Thestaginggradeofthepreoperativechemotherapygroupwerelowerthanthe controlgroup (P<0.05).Thetumordiameter,andtheoperativetimes,theaveragelength ofstay,numberoflymphnodesdissected,bloodlossoftwogroupsshowednosignificant difference(P>0.05).Theexcisionrateoftheadjuvantchemotherapygroupwashigher thanthecontrolgroups(P<0.05).Theomentaladhesions,intestinalobstruction, intestinal edema peripheral tissues, intestinal mucosa hyperemia were lower than the controlgroup(P<0.05).Twogroupsofpatientswerefollowedupfor12to36months;the survivalrateofadjuvantchemotherapygroupwashigher(P<0.05),whilethepathological staging, and recurrenceratewerelowerthan in the controlgroup (P< 0.05). Conclusions Preoperative neoadjuvant chemotherapy in patients with advanced colon cancer can improve the resection rate and long-term survival and reduce the recurrence rate. Legal entity responsiblefor thestudy:MedicalOncologyDepartment2, PLAGeneral Hospital Funding:MedicalOncologyDepartment2,PLAGeneralHospital Disclosure All authors have declared no conflicts ofinterest.