1880 Usefulness of Sentinel Lymph Node Mapping using Indocyanine Green and Fluorescent Imaging in the Diagnosis of Lymph Node Metastasis During Robotic or Laparoscopic Surgery for Endometrial Cancer

Abstract

Study Objective The lymph node status is the most important prognostic factor for endometrial cancer. This study aimed to assess whether sentinel lymph node mapping (SLNM) is applicable in endometrial cancer. Design A retrospective review of patients with endometrial cancer who were diagnosed and treated at a single institute (Asan Medical Center, Seoul, Korea) from September 2015 to December 2017 was conducted. One hundred patients underwent robotic (da Vinci®) or laparoscopic surgical treatment, including SLNM with indocyanine green (ICG) fluorescence detection using the Firefly® and NIR/ICG systems. Setting University Hospital. Patients or Participants 100 patients with early stage endometrial cancer. Interventions Robotic or laparoscopic staging surgery. Measurements and Main Results All patients underwent intraoperative SLNM. At least one lymph node area was observed in 100% of SLNM cases. Sentinel node detection and frozen biopsy were performed in all cases, and all patients with metastasis were found on SLNM. The sensitivity and negative predictive value were both 100% in the patient-by-patient and station-by-station analyses. Conclusion SLNM appears to be a feasible method to reduce the morbidity and increase the detection rate in early-stage endometrial carcinoma.