188. Development of an Immunocompetent Mouse Model of Pancreatic Cancer That Mimics Human Pancreatic Cancer

Abstract

The most common preclinical models of pancreatic cancer utilize immunodeficient hosts into which human xenografts are transplanted. The lack of an intact immune system alters the tumor microenvironment such that these models less accurately recapitulate human disease and therefore may not predict response to therapy in patients with pancreatic cancer. We sought to develop an immunocompetent mouse model of pancreatic cancer and to characterize its immunophenotype.