#187 : The Correlation Between Insulin Resistance with Serum Androgens Levels in Lean Women With and Without PCOS

Abstract

Background and Aims: Polycystic Ovarian Syndrome (PCOS) is a multifactorial disease resulting from the interaction of multiple predisposing genetic variations and environmental factors. Insulin resistance and hyperinsulinemia contribute to hyperandrogenism and impaired gonadotropin secretion by reducing sex hormone binding globulin (SHBG) levels and increasing testosterone bioavailability. However, this insulin resistance is not always present in PCOS patients, especially in lean PCOS patients. This study aims to determine whether insulin resistance correlates with serum androgens levels. Method: We collected 25 samples from lean women with PCOS, and 25 samples from lean women without PCOS. Peripheral whole blood samples will be taken from all samples. Data collected include Anthropometric data, Hormonal profile (using ELISA method), and HOMA-IR value. Results: The result showed that median(min-max) ages for patients was 25(17-34) years. In lean women with PCOS, there was a positive relationship between HOMA-IR with FAI (p=0.017, r=0.472) and negative relationship with SHBG (p=0.001, r=-0.610). Also, in lean women without PCOS, there were no correlation between HOMA-IR with FAI, and HOMA-IR with SHBG (p>0.05) Conclusion: This study shows that there was a correlation between insulin resistance and some serum androgens in lean women with PCOS, but there was no correlation between HOMA-IR with FAI, and HOMA-IR with SHBG in lean women without PCOS. Therefore, the results of this study are hoped to explain the correlation of insulin resistance with serum androgens in lean PCOS patients and can be the basis for further research to find the right solution for the treatment of PCOS patients.