Abstract
The widespread clinical use of ketamine as an antidepressant is limited due to its abuse liability and capacity to produce dissociative effects. Ketamine’s mechanism of antidepressant action has been hypothesized to be due to NMDAR inhibition; however, other NMDAR antagonists do not manifest the full antidepressant actions of ketamine. Ketamine is rapidly and stereospecifically metabolized to norketamine, dehydronorketamine, hydroxyketamine and the hydroxynorketamines (HNKs).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
