187 IS [11C]CHOLINE PET/CT RECOMMENDED FOR RESTAGING PROSTATE CANCER PATIENTS AFTER RADICAL PROSTATECTOMY WHEN PSA IS LOWER THAN 1 NG/ML?

Abstract

You have accessJournal of UrologyProstate Cancer: Staging I1 Apr 2012187 IS [11C]CHOLINE PET/CT RECOMMENDED FOR RESTAGING PROSTATE CANCER PATIENTS AFTER RADICAL PROSTATECTOMY WHEN PSA IS LOWER THAN 1 NG/ML? Manuela Tutolo, Alberto Briganti, Nazareno Suardi, Andrea Gallina, Firas Abdollah, Rita Garcia Parra, Maria Picchio, Giampiero Giovacchini, Luigi Gianolli, Maria Cristina Messa, Ettore Di Trapani, Giuseppe Zanni, Niccolò Maria Passoni, Nicola Fossati, Giorgio Guazzoni, Patrizio Rigatti, and Francesco Montorsi Manuela TutoloManuela Tutolo Milan, Italy More articles by this author , Alberto BrigantiAlberto Briganti Milan, Italy More articles by this author , Nazareno SuardiNazareno Suardi Milan, Italy More articles by this author , Andrea GallinaAndrea Gallina Milan, Italy More articles by this author , Firas AbdollahFiras Abdollah Milan, Italy More articles by this author , Rita Garcia ParraRita Garcia Parra Milan, Italy More articles by this author , Maria PicchioMaria Picchio Milan, Italy More articles by this author , Giampiero GiovacchiniGiampiero Giovacchini Milan, Italy More articles by this author , Luigi GianolliLuigi Gianolli Milan, Italy More articles by this author , Maria Cristina MessaMaria Cristina Messa Milan, Italy More articles by this author , Ettore Di TrapaniEttore Di Trapani Milan, Italy More articles by this author , Giuseppe ZanniGiuseppe Zanni Milan, Italy More articles by this author , Niccolò Maria PassoniNiccolò Maria Passoni Milan, Italy More articles by this author , Nicola FossatiNicola Fossati Milan, Italy More articles by this author , Giorgio GuazzoniGiorgio Guazzoni Milan, Italy More articles by this author , Patrizio RigattiPatrizio Rigatti Milan, Italy More articles by this author , and Francesco MontorsiFrancesco Montorsi Milan, Italy More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.239AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES [11C]choline PET/CT is currently recommended in restaging prostate cancer (PCa) patients previously treated with radical prostatectomy (RP) when prostate-specific antigen (PSA) values are higher than 1 ng/mL. The role of clinical and pathological variables in patients with lower PSA values to detect early PC recurrences by [11C]choline PET/CT was investigated. METHODS A total of 72 patients (mean age: 66 years, range: 51-80 years), treated with RP for PCa, who showed during follow-up (FU) a mild increase (< 1 ng/mL) of PSA serum levels (mean PSA: 0,57 ng/mL, range: 0,22-0,99 ng/mL) were retrospectively evaluated. Inclusion criterion was previous RP treatment and biochemical failure, defined as at least two consecutive PSA measurements greater than 0,2 ng/mL. [11C]choline PET/CT findings were validated using histological and follow-up clinical and imaging criteria in all cases. In order to identify predictive factors of a positive [11C]choline PET/CT, Cox regression analyses was using the following variables: age, Gleason Score, TNM staging, time from RP to the biochemical relapse, anti-androgen therapy at the time of [11C]choline PET/CT scan, trigger PSA value, PSA doubling time (PSADT) and PSA velocity (PSAV). RESULTS [11C]choline PET/CT suggested the presence of recurrences in 17/72 patients (23,6%): 6/17 (35,3%) in prostatectomy bed; 6/17 (35,3%) at lymph nodal level and 5/17 (29,4%) in the skeleton. At Cox regression analyses performed in patients with PSA increase < 1 ng/mL, only advanced pathological stage and short PSADT were significant (P < 0.05) predictors of positive [11C]choline PET/CT. CONCLUSIONS [11C]choline PET/CT can be useful in patients with PSA < 1 ng/mL, reporting a detection rate of recurrent disease in 24% of patients. Patients with PSA increase < 1 ng/mL after radical prostatectomy may be referred to [11C]choline PET/CT when advanced pathological stage and short PSADT occur. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e78-e79 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Manuela Tutolo Milan, Italy More articles by this author Alberto Briganti Milan, Italy More articles by this author Nazareno Suardi Milan, Italy More articles by this author Andrea Gallina Milan, Italy More articles by this author Firas Abdollah Milan, Italy More articles by this author Rita Garcia Parra Milan, Italy More articles by this author Maria Picchio Milan, Italy More articles by this author Giampiero Giovacchini Milan, Italy More articles by this author Luigi Gianolli Milan, Italy More articles by this author Maria Cristina Messa Milan, Italy More articles by this author Ettore Di Trapani Milan, Italy More articles by this author Giuseppe Zanni Milan, Italy More articles by this author Niccolò Maria Passoni Milan, Italy More articles by this author Nicola Fossati Milan, Italy More articles by this author Giorgio Guazzoni Milan, Italy More articles by this author Patrizio Rigatti Milan, Italy More articles by this author Francesco Montorsi Milan, Italy More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...