Abstract
The stratified skin epidermis needs dynamic cell rearrangement to self-renew while maintaining tissue integrity to guarantee barrier function in the face of continuous mechanical stress. The contractile actomyosin cytoskeleton connects with intercellular adheres junctions to enable cellular rearrangements and migration, whereas the physical properties of the keratin intermediate filament cytoskeleton through its interaction with intercellular desmosomes mechanically strengthen tissues. How cells coordinate resilience and cellular reorganization to maintain tissue integrity during renewal while adapting to mechanical stress is not known.
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