Abstract
Background: Amplification and/or overexpression of HER2 in breast cancer (BC) patients is associated with aggressive disease and poor prognosis. Herceptin® (trastuzumab), a monoclonal antibody targeting HER2 in combination with anthracycline- and taxane-based neoadjuvant treatment in women with HER2-positive BC has resulted in improvements in pathological complete response (pCR), event-free survival (EFS) and overall survival (OS). This study was designed to compare efficacy (pCR) and safety between the originator Herceptin® and the proposed trastuzumab biosimilar EG12014.
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