183P Prognostic value of high mesenchymal-epithelial transition factor gene (MET) expression in patients with estrogen receptor positive (ER+), human epidermal growth factor receptor negative (HER2-) early breast cancer

Abstract

High c-Met expression is involved in human carcinogenesis, tumour progression and resistance to antineoplastic treatments in several human malignancies. The c-Met receptor is overexpressed in about 20-30% of invasive breast cancers, but its prognostic value in clinical practice is still debated.