Abstract
Filaggrin (FLG) is a key cornified envelope and epidermal barrier protein. FLG mutations are the most strongly implicated genetic risk factor for atopic eczema (AE). FLG is part of a gene complex, called the epidermal differentiation complex (EDC), the genes of which contribute to various aspects of epidermal barrier function. FLG siRNA knockdown in keratinocytes caused a global reduction in EDC and Keratin (KRT) gene expression concomitant with up-regulation of bone morphogenetic protein (BMP) signalling.
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