Abstract
G A A b st ra ct s cells from Naive (CD44-CD45RBhi) to memory (CD44+CD45RBlo) CD4+ T cells. Concomitantly, the percentage of Foxp3+Tregs was decreased in the intestine of mice with NEC (2.1±0.4) compared to dam-fed controls (6.6±0.7) (p,0.001), which could be restored to normal (5.1±0.8, p,0.05) by LR17938 feeding. CONCLUSIONS: CD4+CD44+CD45RBlo/ hiFoxp3effector T cells and Foxp3+ Tregs were inversely altered by LR17938 feeding in the intestine of mice with NEC. These T cell subsets might be potential biomarkers and new therapeutic targets during intestinal inflammation.
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