Abstract
Mandelic acid is a lipophilic alpha hydroxyacid (AHA) with known antibacterial properties. As such, mandelic acid was evaluated for its benefits on oily and photoaged skin. Mandelic acid and glycolic acid were incubated with cultured sebocytes in vitro to measure changes in lipid production via Nile Red staining. In vivo exfoliation of a mandelic acid cleanser or cream (2%; twice daily) was assessed using the fluorescent dye dansyl chloride and UV image analysis. An 8-week anti-aging clinical study on women (30-50 years) with mild to moderate oily skin assessed a facial gel cream (twice daily) containing mandelic acid in combination with other benefit ingredients.
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