Abstract

Duodenal carcinomas (DC) are malignancies from the small bowel that can overlap pancreatobiliary (PBC) and colon cancer (CC) in histologic and molecular features. In this study, we assessed the somatic mutational landscapes of a combined cohort of DC, PBC, and CC from 19 institutions participating in the GENIE Consortium Cohort (v9.0) and examined the differential mutational landscape of DC as compared with PBC and CC, along with the clinical actionability of unique mutations identified in DC.

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