Abstract
We have previously shown that SSTR5 is an important regulator of insulin expression/secretion and islet proliferation via pancreatic-duodenal homeobox 1(PDX-1) in mice. We have also identified a germline, non-synonymous single nucleotide polymorphism (SNP) of SSTR5 in human blood and pancreatic cancer specimens, which results in mutation of intracellular C-terminal proline 335 to leucine (SSTR5 P335L). The purpose of this study was to determine whether SSTR5 P335L SNP has any functional significance on PDX-1 expression and proliferation in human cell lines.
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