1814 SEVEN YEARS OF EXPERIENCE WITH HIGH-INTENSITY FOCUSED ULTRASOUND FOR PROSTATE CANCER: ADVANTAGES AND LIMITATIONS

Abstract

You have accessJournal of UrologyProstate Cancer: Localized IX1 Apr 20121814 SEVEN YEARS OF EXPERIENCE WITH HIGH-INTENSITY FOCUSED ULTRASOUND FOR PROSTATE CANCER: ADVANTAGES AND LIMITATIONS Hyun Hwan Sung, Hyung Joon Kim, Bumsoo Park, Bong Hee Park, Sin-Woo Lee, Joong Seo Ahn, Jung Hun Kang, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Han Yong Choi, and Hyun Moo Lee Hyun Hwan SungHyun Hwan Sung Seoul, Korea, Republic of More articles by this author , Hyung Joon KimHyung Joon Kim Seoul, Korea, Republic of More articles by this author , Bumsoo ParkBumsoo Park Seoul, Korea, Republic of More articles by this author , Bong Hee ParkBong Hee Park Seoul, Korea, Republic of More articles by this author , Sin-Woo LeeSin-Woo Lee Seoul, Korea, Republic of More articles by this author , Joong Seo AhnJoong Seo Ahn Seoul, Korea, Republic of More articles by this author , Jung Hun KangJung Hun Kang Seoul, Korea, Republic of More articles by this author , Byong Chang JeongByong Chang Jeong Seoul, Korea, Republic of More articles by this author , Seong Il SeoSeong Il Seo Seoul, Korea, Republic of More articles by this author , Seong Soo JeonSeong Soo Jeon Seoul, Korea, Republic of More articles by this author , Han Yong ChoiHan Yong Choi Seoul, Korea, Republic of More articles by this author , and Hyun Moo LeeHyun Moo Lee Seoul, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1880AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES High-intensity focused ultrasound (HIFU) is one of the minimally invasive surgeries for prostate cancer. The aim of this study was to evaluate oncologic outcomes according to risk stratification as well as complication rates for patients with prostate cancer after treatment by high-intensity focused ultrasound (HIFU). METHODS From February 2004 to August 2010, we identified 157 patients with prostate cancer who underwent a single session of HIFU. BCR was defined as PSA nadir plus 1.2 ng/ml using the Stuttgart definition. Kaplan-Meier analysis was performed to evaluate BCR and disease progression survival according to the National Comprehensive Cancer Network stratification. Predictors for BCR and disease progression were identified using the Cox-proportional hazard method. Postoperative adverse events were recorded. RESULTS A total of 126 patients were included. The overall BCR rate was 59.5%, and median time to BCR was 13.8 months. The 5-year BCR-free survival rates of the low-, intermediate-, and high-risk groups were 66.3%, 40.2% and 21.0% (P = 0.001), respectively, and the 5-year disease progression-free survival rates were 73.5%, 46.0% and 29.2%, respectively (P = 0.008). Significant differences were also found according to the stratification by PSA nadir for BCR- and progression-free survival rates (P < 0.001 in both). Multivariate analysis showed that risk stratification, PSA nadir, and time to PSA nadir were significant predictors of BCR and disease progression. In the first 3 months post-op, 11 patients (8.7%) had complications. There were no patients who required blood transfusions or who had wound problems, stroke, deep vein thrombosis, or bowel dysfunction. At the last evaluation incontinence rate was 6.3%, and impotence rate was 73.7%. CONCLUSIONS A single session of HIFU treatment does not provide effective oncologic outcomes even in low risk patients with prostate cancer as well as in the intermediate or high risk groups. Therefore, patients selected to undergo HIFU treatment for prostate cancer must be very carefully chosen. On the other hand, HIFU treatment for prostate cancer had a very low rate of complications. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e733 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Hyun Hwan Sung Seoul, Korea, Republic of More articles by this author Hyung Joon Kim Seoul, Korea, Republic of More articles by this author Bumsoo Park Seoul, Korea, Republic of More articles by this author Bong Hee Park Seoul, Korea, Republic of More articles by this author Sin-Woo Lee Seoul, Korea, Republic of More articles by this author Joong Seo Ahn Seoul, Korea, Republic of More articles by this author Jung Hun Kang Seoul, Korea, Republic of More articles by this author Byong Chang Jeong Seoul, Korea, Republic of More articles by this author Seong Il Seo Seoul, Korea, Republic of More articles by this author Seong Soo Jeon Seoul, Korea, Republic of More articles by this author Han Yong Choi Seoul, Korea, Republic of More articles by this author Hyun Moo Lee Seoul, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...